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KMID : 0043320170400060720
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Archives of Pharmacal Research
2017 Volume.40 No. 6 p.720 ~ p.726
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Microbial transformation of naringenin derivatives
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Xiao Yi Na
Lee Ik-Soo
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Abstract
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Microbial transformations of (±)-7-O-prenylnaringenin (7-PN, 1) and (±)-7-O-allylnaringenin (7-AN, 2) have isolated four metabolites (3?6). Structures of these novel compounds were identified as 5,4′-dihydroxy-7-O-[(2E)-4-hydroxy-3-methyl-2-buten-1-yl]flavanone (3), 5,4′-dihydroxy-7-O-(2,3-dihdroxy-3-methylbutyl)flavanone (4), 5,4′-dihydroxy-7-O-(2,3-dihdroxypropyl)flavanone (5), and 5-O-β-D-glucopyranosyl-7-O-allyl-4′-hydroxyflavanone (6) based on spectroscopy. Compounds 1?6 were evaluated for their radical scavenging capacity using DPPH (2,2-diphenyl-1-picrylhydrazyl). The derivatives 3?6 exhibited more potent antioxidant activity than their corresponding substrates 1 and 2.
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KEYWORD
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Microbial transformation, 7-O-prenylnaringenin, 7-O-allylnaringenin, DPPH
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